000 02897nab a2200361 c 4500
001 vtls000788203
003 RU-ToGU
005 20230319221558.0
007 cr |
008 201113|2018 xxu s a eng d
024 7 _a10.1364/BOE.9.004443
_2doi
035 _ato000788203
040 _aRU-ToGU
_brus
_cRU-ToGU
245 1 0 _aModified wavelength scanning interferometry for simultaneous tomography and topography of the cornea with Fourier domain optical coherence tomography
_cS. Das, C. Liu, M. Singh [et al.]
336 _aТекст
337 _aэлектронный
504 _aБиблиогр.: 52 назв.
520 3 _aVisual acuity is dependent on corneal shape and size. A minor variation in surface geometry can cause a deformation of corneal geometry, which affects its optical performance. In this work we demonstrate an algorithm for the simultaneous measurement of corneal tomography and topography with a traditional point-scanning Fourier domain optical coherence tomography (FD-OCT) system. A modified wavelength scanning interferometry (mWSI) algorithm enabled topographical evaluation of the surface with nanometer-scale resolution, which is superior to the micrometer-scale resolution of traditional OCT structural imaging. We validated the technique with an optically flat mirror, standard roughness gauges, and atomic force microscopy (AFM). The mirror results show nanometer-scale sensitivity (~3.5 nm), and the mWSI measurements were in good agreement (error ~5%) with the specifications of the roughness comparator and AFM, demonstrating the accuracy of the technique. Following validation, the measurements were made on pig corneas in situ at various artificially controlled intraocular pressures (IOP) and before and after cross-linking (CXL). The results show that the mean surface roughness increased by ~65% after removal of the epithelium in preparation for CXL but did not change as a function of IOP. The demonstrated method could be used for simultaneous measurement of tissue tomography with micrometer-precision and topography with nanometer-precision.
653 _aтопография роговицы
653 _aтомография роговицы
653 _aоптическая когерентная томография
655 4 _aстатьи в журналах
_9879358
700 1 _aLiu, Chih-Hao
_9153791
700 1 _aSingh, Manmohan
_9153788
700 1 _aTwa, Michael D.
_9480030
700 1 _aLarin, Kirill V.
_9153792
700 1 _aDas, Susobhan
_9484160
773 0 _tBiomedical optics express
_d2018
_gVol. 9, № 9. P. 4443-4458
_x2156-7085
852 4 _aRU-ToGU
856 4 _uhttp://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000788203
908 _aстатья
999 _c474292