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008 170212s2015 sz | s |||| 0|eng d
020 _a9783034809559
_9978-3-0348-0955-9
024 7 _a10.1007/978-3-0348-0955-9
_2doi
035 _ato000557155
040 _aSpringer
_cSpringer
_dRU-ToGU
050 4 _aQP110.G45
072 7 _aMFN
_2bicssc
072 7 _aMED107000
_2bisacsh
072 7 _aSCI029000
_2bisacsh
082 0 4 _a611.01816
_223
245 1 0 _aCirculating microRNAs in Disease Diagnostics and their Potential Biological Relevance
_helectronic resource
_cedited by Peter Igaz.
250 _a1st ed. 2015.
260 _aBasel :
_bSpringer Basel :
_bImprint: Springer,
_c2015.
300 _aXII, 288 p. 18 illus., 15 illus. in color.
_bonline resource.
336 _atext
_btxt
_2rdacontent
337 _acomputer
_bc
_2rdamedia
338 _aonline resource
_bcr
_2rdacarrier
490 1 _aExperientia Supplementum,
_x1023-294X ;
_v106
505 0 _aPart I: General features and technical issues related to circulating microRNA -- 1. Introduction to microRNAs: biogenesis, action, relevance of tissue microRNAs in disease pathogenesis, diagnosis and therapy. The concept of circulating microRNAs -- 2. Extracellular microRNAs in membrane vesicles and non-vesicular carriers -- 3. Technical aspects related to the analysis of circulating microRNAs -- Part II: Diagnostic relevance of circulating microRNAs -- 4. Circulating blood-borne microRNAs as biomarkers in solid tumors -- 5. Circulating microRNA as biomarkers in hematological malignancies -- 6 Circulating microRNAs as biomarkers in cardiovascular diseases -- 7 Circulating microRNAs in neurodegenerative diseases -- 8 Circulating extracellular microRNA in systemic autoimmunity -- 9. Circulating microRNAs in inflammatory bowel diseases -- 10. Circulating microRNAs in diabetes progression: discovery, validation and research translation -- 11. Diagnostic relevance of microRNAs in other body fluids including urine, feces and saliva -- Part III: Potential biological relevance of circulating microRNA -- 12 Circulating microRNAs as hormones – intercellular and inter-organ conveyors of epigenetic information? -- 13. Are circulating microRNAs involved in tumor surveillance? -- 14.-Hypothetic interindividual and interspecies relevance of microRNAs released in body fluids.
520 _aMicroRNAs as the endogenous mediators of RNA interference have experienced an unprecedented career in recent years, highlighting their pathogenic, diagnostic and potential therapeutic relevance. Beside tissue microRNAs, they are also found in body fluids, most notably in blood. Significant differences of circulating microRNA levels have been found in various diseases, making them candidates for minimally invasive markers of disease, for example tumor malignancy. The book focuses on the potential diagnostic applicability of circulating microRNAs in various diseases and their potential biological significance.
650 0 _amedicine.
_9566220
650 0 _aGene expression.
_9567143
650 0 _aMedical Biochemistry.
_9299063
650 0 _aNucleic acids.
_9412278
650 1 4 _aBiomedicine.
_9566246
650 2 4 _aGene Expression.
_9567144
650 2 4 _aNucleic Acid Chemistry.
_9412279
650 2 4 _aMedical Biochemistry.
_9299063
700 1 _aIgaz, Peter.
_eeditor.
_9461585
710 2 _aSpringerLink (Online service)
_9143950
773 0 _tSpringer eBooks
830 0 _aExperientia Supplementum,
_9566551
856 4 0 _uhttp://dx.doi.org/10.1007/978-3-0348-0955-9
912 _aZDB-2-SBL
999 _c411661