The laser technologies of targeted opening of blood-brain barrier for drug brain delivery O. V. Semyachkina-Glushkovskaya, E. U. Rafailov, S. G. Sokolovsky [et al.]
Material type:
ArticleSubject(s): гематоэнцефалический барьер | лазерные технологии | фотодинамическая терапияGenre/Form: статьи в сборниках Online resources: Click here to access online
In:
International Conference Laser Optics 2018 (ICLO 2018), St. Petersburg, Russia, 4-8 June, 2018 : proceedings P. 501Abstract: Here we show the photodynamic treatment
(PDT) causes significant increase in the permeability of the
blood-brain barrier (BBB) in healthy mice. Using different
doses of laser (635 nm, 10-40 J/cm2) and photosensitizer (5-
aminole-vulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we
found the optimal PDT for the reversible opening of BBB
that is 15 J/cm2 and 5-ALA, 20 mg/kg, when the brain
tissues recover 3 days later. Further increase in the laser
or 5-ALA doses has not amplifying effect on the BBB but
associated with severe damages of brain tissues. These
results can be good informative platform for the further
studies of new strategies in brain drug delivery and for the
better understanding of mechanisms underlying
cerebrovascular effects of PD-related fluorescence guided
resection of brain tumor.
Here we show the photodynamic treatment
(PDT) causes significant increase in the permeability of the
blood-brain barrier (BBB) in healthy mice. Using different
doses of laser (635 nm, 10-40 J/cm2) and photosensitizer (5-
aminole-vulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we
found the optimal PDT for the reversible opening of BBB
that is 15 J/cm2 and 5-ALA, 20 mg/kg, when the brain
tissues recover 3 days later. Further increase in the laser
or 5-ALA doses has not amplifying effect on the BBB but
associated with severe damages of brain tissues. These
results can be good informative platform for the further
studies of new strategies in brain drug delivery and for the
better understanding of mechanisms underlying
cerebrovascular effects of PD-related fluorescence guided
resection of brain tumor.
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