In vitro terahertz spectroscopy of gelatin-embedded human brain tumors - a pilot study N. V. Chernomyrdin, A. A. Gavdush, S.-I.T. Beshplav [et al.]
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ArticleSubject(s): терагерцовая импульсная спектроскопия | опухоль головного мозга | злокачественная глиома | менингиома | интраоперационная диагностикаGenre/Form: статьи в журналах Online resources: Click here to access online
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Proceedings of SPIE Vol. 10716 : Saratov fall meeting 2017 : Optical technologies in biophysics and medicine XIX, 26-30 September 2017, Saratov, Russian Federation. P. 107160S-1-107160S-9Abstract: We have performed the in vitro terahertz (THz) spectroscopy of human brain tumors. In order to x tissues
for the THz measurements, we have applied the gelatin embedding. It allows for preserving tissues from hydra-
tion/dehydration and sustaining their THz response similar to that of the freshly-excised tissues for a long time
after resection. We have assembled an experimental setup for the re
ection-mode measurements of human brain
tissues based on the THz pulsed spectrometer. We have used this setup to study in vitro the refractive index
and the amplitude absorption coecient of 2 samples of malignant glioma (grade IV), 1 sample of meningioma
(grade I), and samples of intact tissues. We have observed signicant dierences between the THz responses
of normal and pathological tissues of the brain. The results of this paper highlight the potential of the THz
technology in the intraoperative neurodiagnosis of tumors relying on the endogenous labels of tumorous tissues.
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We have performed the in vitro terahertz (THz) spectroscopy of human brain tumors. In order to x tissues
for the THz measurements, we have applied the gelatin embedding. It allows for preserving tissues from hydra-
tion/dehydration and sustaining their THz response similar to that of the freshly-excised tissues for a long time
after resection. We have assembled an experimental setup for the re
ection-mode measurements of human brain
tissues based on the THz pulsed spectrometer. We have used this setup to study in vitro the refractive index
and the amplitude absorption coecient of 2 samples of malignant glioma (grade IV), 1 sample of meningioma
(grade I), and samples of intact tissues. We have observed signicant dierences between the THz responses
of normal and pathological tissues of the brain. The results of this paper highlight the potential of the THz
technology in the intraoperative neurodiagnosis of tumors relying on the endogenous labels of tumorous tissues.
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