Оценка противоопухолевой эффективности различных видов ИПМИ в сочетанном действии с доксорубицином in vitro Е. А. Просекина
Material type:
ArticleOther title: Antitumor therapy efficiency of different types of nanosecond pulseperiodic microwave radiation in combination with doxorubicin in vitro [Parallel title]Subject(s): импульсно-периодическое микроволновое излучение | in vitro технологии | доксорубицин | облучение | клеточная пролиферация | опухолевые клеткиGenre/Form: статьи в сборниках Online resources: Click here to access online
In:
Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, 24-27 апреля 2018 г Т. 4 : Биология и фундаментальная медицина. С. 122-124Abstract: It is known that the action of high-amplitude electric pulses can significantly increase the permeability of cell membranes due to the formation ofpores in them (electroporation). The aim of this research was to study the possibility of forming electropores in membranes of tumor cells by means of a non-invasive method using nanosecond microwave pulses for effective delivery of chemotherapeutic agents to the cell. The HeLa cell line was used as a model object. Doxorubicin was used as a chemotherpeutic drug in various concentrations: 0.5,
1.0 and 2.5 pM. Radiation was carried out on two sources of pulsed-periodic microwave radiation, characterized by different parameters. It was found that, 24 hours after exposure at pulse repetition rates of 13 and 16 Hz in combination with doxorubicin, there was an increase in inhibition of tumor cell proliferation by 30 and 40 %, respectively.
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It is known that the action of high-amplitude electric pulses can significantly increase the permeability of cell membranes due to the formation ofpores in them (electroporation). The aim of this research was to study the possibility of forming electropores in membranes of tumor cells by means of a non-invasive method using nanosecond microwave pulses for effective delivery of chemotherapeutic agents to the cell. The HeLa cell line was used as a model object. Doxorubicin was used as a chemotherpeutic drug in various concentrations: 0.5,
1.0 and 2.5 pM. Radiation was carried out on two sources of pulsed-periodic microwave radiation, characterized by different parameters. It was found that, 24 hours after exposure at pulse repetition rates of 13 and 16 Hz in combination with doxorubicin, there was an increase in inhibition of tumor cell proliferation by 30 and 40 %, respectively.
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