Correction of the toxic effect of cyclophosphamide on hemopoiesis in animals with lewis lung carcinoma using low-molecular-weight sodium alginate O. Yu. Rybalkina, N. N. Ermakova, T. G. Razina [et.al.]
Material type:
ArticleSubject(s): альгинат натрия | Льюиса карцинома легких | мыши | циклофосфамид | гемопоэз | химиотерапияGenre/Form: статьи в журналах Online resources: Click here to access online
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Russian journal of marine biology Vol. 41, № 5. P. 389-396Abstract: The influence of low-molecular-weight sodium alginate, which is administered as an isolated agent and in combination with cyclophosphamide, on the parameters of peripheral blood and bone marrow was studied in mice with Lewis lung carcinoma. It was shown that administration of sodium alginate with a molecular weight of 1–10 and 20–30 kDa to tumor-bearing animals prevents bone marrow failure by activating the process of regeneration of granulocytic hemopoietic stem cells that are damaged by a single injection or repetitive injections of a cytostatic agent, due to stimulation of the clonal activity of granulocytopoiesis precursors. As a result, this treatment prevents the progression of leukopenia.
Библиогр.: 36 назв.
The influence of low-molecular-weight sodium alginate, which is administered as an isolated agent and in combination with cyclophosphamide, on the parameters of peripheral blood and bone marrow was studied in mice with Lewis lung carcinoma. It was shown that administration of sodium alginate with a molecular weight of 1–10 and 20–30 kDa to tumor-bearing animals prevents bone marrow failure by activating the process of regeneration of granulocytic hemopoietic stem cells that are damaged by a single injection or repetitive injections of a cytostatic agent, due to stimulation of the clonal activity of granulocytopoiesis precursors. As a result, this treatment prevents the progression of leukopenia.
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