pH-triggered delivery of magnetic nanoparticles depends on tumor volume A. G. Pershina, O. Ya. Brikunova, A. M. Demin [et al.]
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ArticleContent type: Текст Media type: электронный Subject(s): магнитные наночастицы | оксид железа | магнитно-резонансная томография | опухолиGenre/Form: статьи в журналах Online resources: Click here to access online
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Nanomedicine: Nanotechnology, biology, and medicine Vol. 23. P. 102086 (1-8)Abstract: Nowadays there is growing recognition of the fact that biological systems have a greater impact on nanoparticle target delivery in tumors
than nanoparticle design. Here we investigate the targeted delivery of Fe3O4 magnetic nanoparticles conjugated with pH-low-insertion
peptide (MNP-pHLIP) on orthotopically induced MDA-MB-231 human breast carcinoma xenografts of varying volumes as a model of
cancer progression. Using in vivo magnetic resonance imaging and subsequent determination of iron content in tumor samples by inductively
coupled plasma atomic emission spectroscopy we found that MNP-pHLIP accumulation depends on tumor volume. Transmission electron
microscopy, histological analysis and immunohistochemical staining of tumor samples suggest that blood vessel distribution is the key factor
in determining the success of the accumulation of nanoparticles in tumors.
© 2019 Elsevier Inc. All rights reserved.
Библиогр.: 30 назв.
Nowadays there is growing recognition of the fact that biological systems have a greater impact on nanoparticle target delivery in tumors
than nanoparticle design. Here we investigate the targeted delivery of Fe3O4 magnetic nanoparticles conjugated with pH-low-insertion
peptide (MNP-pHLIP) on orthotopically induced MDA-MB-231 human breast carcinoma xenografts of varying volumes as a model of
cancer progression. Using in vivo magnetic resonance imaging and subsequent determination of iron content in tumor samples by inductively
coupled plasma atomic emission spectroscopy we found that MNP-pHLIP accumulation depends on tumor volume. Transmission electron
microscopy, histological analysis and immunohistochemical staining of tumor samples suggest that blood vessel distribution is the key factor
in determining the success of the accumulation of nanoparticles in tumors.
© 2019 Elsevier Inc. All rights reserved.
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