Photodynamic therapy of brain tumors and novel optical coherence tomography strategies for in vivo monitoring of cerebral fluid dynamics A. Abdurashitov, V. V. Tuchin, O. V. Semyachkina-Glushkovskaya
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ArticleContent type: Текст Media type: электронный Subject(s): фотодинамическая терапия | оптическая когерентная томография | опухоль головного мозга | цереброспинальная жидкостьGenre/Form: статьи в журналах Online resources: Click here to access online
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Journal of innovative optical health sciences Vol. 13, № 2. P. 2030004-1-2030004-20Abstract: Photodynamic therapy (PDT) is a promising tool for least-invasive alternative methods for the
treatment of brain tumors. The newly discovered PDT-induced opening of the blood–brain
barrier (BBB) permeability open novel strategies for drug-brain delivery during post-surgical
treatment of glioblastoma GBM. Here we discuss mechanisms of PDT-mediated opening of the
BBB and age di®erences in PDT-related increase in BBB permeability, including with formation
of brain edema. The meningeal lymphatic system plays a crucial role in the mechanism of brain
drainage and clearance from metabolites and toxic molecules. We discuss that noninvasive
photonic stimulation of °uid clearance via meningeal lymphatic vessels, and application of optical
coherence tomography (OCT) for bed-side monitoring of meningeal lymphatic drainage has the
promising perspective to be widely applied in both experimental and clinical studies of PDT and
improving guidelines of PDT of brain tumors.
Библиогр.: 144 назв.
Photodynamic therapy (PDT) is a promising tool for least-invasive alternative methods for the
treatment of brain tumors. The newly discovered PDT-induced opening of the blood–brain
barrier (BBB) permeability open novel strategies for drug-brain delivery during post-surgical
treatment of glioblastoma GBM. Here we discuss mechanisms of PDT-mediated opening of the
BBB and age di®erences in PDT-related increase in BBB permeability, including with formation
of brain edema. The meningeal lymphatic system plays a crucial role in the mechanism of brain
drainage and clearance from metabolites and toxic molecules. We discuss that noninvasive
photonic stimulation of °uid clearance via meningeal lymphatic vessels, and application of optical
coherence tomography (OCT) for bed-side monitoring of meningeal lymphatic drainage has the
promising perspective to be widely applied in both experimental and clinical studies of PDT and
improving guidelines of PDT of brain tumors.
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