Поиск молекулярных маркеров инвазивного роста рака молочной железы, связь их экспрессии с прогнозом заболевания Н. М. Новиков, Т. С. Геращенко, Н. В. Крахмаль
Material type:
ArticleOther title: Search for maricers of invasive growth in breast cancer: association with disease prognosis [Parallel title]Subject(s): рак молочной железы | молекулярные маркеры | инвазия | экспрессия белковGenre/Form: статьи в сборниках Online resources: Click here to access online
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Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, 24-27 апреля 2018 г Т. 4 : Биология и фундаментальная медицина. С. 116-118Abstract: In the present study, we analyzed the gene expression profdes of various morphological structures of breast cancer (GEO, GSE80754) to identify new markers of invasion and to assess their association with disease prognosis. Nine proteins (KIE14, DSC3, WAVE, etc.) was selected based on the literature analysis of the involvement of genes up- and down-regulated in solid and trabecular structures in cancer invasion and a heterogeneity in expression of their proteins in breast tumors. The association of these proteins with patients ’ survival was assessed.
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In the present study, we analyzed the gene expression profdes of various morphological structures of breast cancer (GEO, GSE80754) to identify new markers of invasion and to assess their association with disease prognosis. Nine proteins (KIE14, DSC3, WAVE, etc.) was selected based on the literature analysis of the involvement of genes up- and down-regulated in solid and trabecular structures in cancer invasion and a heterogeneity in expression of their proteins in breast tumors. The association of these proteins with patients ’ survival was assessed.
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