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Involvement of PI3K, MAPK ERK1/2 and p38 in functional stimulation of mesenchymal progenitor cells by alkaloid songorine G. N. Zyuz'kov, V. V. Zhdanov, E. E. Shults [et.al.]
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ArticleSubject(s): клетки-предшественники | мезенхимальные клеткиGenre/Form: статьи в журналах Online resources: Click here to access online
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Bulletin of experimental biology and medicine Vol. 159, № 1. P. 58-61Abstract: We studied the role of intracellular signaling molecules PI3K, МАРK ERK1/2, and р38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and р38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and р38 reduced the intensity of progenitor cell differentiation.
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Библиогр.: 15 назв.
We studied the role of intracellular signaling molecules PI3K, МАРK ERK1/2, and р38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and р38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and р38 reduced the intensity of progenitor cell differentiation.
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