Tumour stem cells in breast cancer M. K. Ibragimova, M. M. Tsyganov, N. V. Litviakov
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ArticleContent type: Текст Media type: электронный Subject(s): раковые стволовые клетки | рак молочной железы | метастазирование | пластичностьGenre/Form: статьи в журналах Online resources: Click here to access online
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International journal of molecular sciences Vol. 23, № 9. P. 5058 (1-21)Abstract: Tumour stem cells (CSCs) are a self-renewing population that plays important roles in tumour initiation, recurrence, and metastasis. Although the medical literature is extensive, problems with CSC identification and cancer therapy remain. This review provides the main mechanisms of CSC action in breast cancer (BC): CSC markers and signalling pathways, heterogeneity, plasticity, and ecological behaviour. The dynamic heterogeneity of CSCs and the dynamic transitions of CSC- non-CSCs and their significance for metastasis are considered.
Библиогр.: 184 назв.
Tumour stem cells (CSCs) are a self-renewing population that plays important roles in tumour initiation, recurrence, and metastasis. Although the medical literature is extensive, problems with CSC identification and cancer therapy remain. This review provides the main mechanisms of CSC action in breast cancer (BC): CSC markers and signalling pathways, heterogeneity, plasticity, and ecological behaviour. The dynamic heterogeneity of CSCs and the dynamic transitions of CSC- non-CSCs and their significance for metastasis are considered.
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