In vivo quantification of the effectiveness of topical low-dose photodynamic therapy in wound healing using two-photon microscopy H. Zuhayri, V. V. Nikolaev, A. I. Knyazkova [et al.]
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ArticleContent type: Текст Media type: электронный Subject(s): лечение раны | фотодинамическая терапия | низкие дозы | фотосенсибилизаторы | двухфотонная микроскопия | генерация второй гармоники | автофлуоресценцияGenre/Form: статьи в журналах Online resources: Click here to access online
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Pharmaceutics Vol. 14, № 2. P. 287 (1-17)Abstract: The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm2). A second-harmonic-generation-to-auto-fluorescence aging index of the dermis (SAAID) was analyzed by two-photon microscopy. SAAID measured at 60–80 μm depths was shown to be a suitable quantitative parameter to monitor wound healing. A comparison of SAAID in healthy and wound tissues during phototherapy showed that both light doses were effective for wound healing; however, healing was better at a dose of 4 J/cm2.
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The effect of low-dose photodynamic therapy on in vivo wound healing with topical application of 5-aminolevulinic acid and methylene blue was investigated using an animal model for two laser radiation doses (1 and 4 J/cm2). A second-harmonic-generation-to-auto-fluorescence aging index of the dermis (SAAID) was analyzed by two-photon microscopy. SAAID measured at 60–80 μm depths was shown to be a suitable quantitative parameter to monitor wound healing. A comparison of SAAID in healthy and wound tissues during phototherapy showed that both light doses were effective for wound healing; however, healing was better at a dose of 4 J/cm2.
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