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The in vivo quantitative assessment of the effectiveness of low-dose photodynamic therapy on wound healing using optical coherence tomography H. Zuhayri, V. V. Nikolaev, T. B. Lepekhina [et al.]

Contributor(s): Zuhayri, Hala | Nikolaev, Viktor V | Lepekhina, Tatiana B | Sandykova, Ekaterina A | Krivova, Natalya A | Kistenev, Yury VMaterial type: ArticleArticleContent type: Текст Media type: электронный Subject(s): фотодинамическая терапия | низкие дозы | лечение раны | 5-аминолевулиновая кислота | метиленовый синий | оптическая когерентная томографияGenre/Form: статьи в журналах Online resources: Click here to access online In: Pharmaceutics Vol. 14, № 2. P. 399 (1-13)Abstract: The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound’s state during wound healing including the effect of low-dose photodynamic therapy using topical application of two different photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser doses of 1 J/cm2 and 4 J/cm2. It was concluded that the laser dose of 4 J/cm2 was better compared to 1 J/cm2 and allowed the wound healing process to accelerate.
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The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound’s state during wound healing including the effect of low-dose photodynamic therapy using topical application of two different photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser doses of 1 J/cm2 and 4 J/cm2. It was concluded that the laser dose of 4 J/cm2 was better compared to 1 J/cm2 and allowed the wound healing process to accelerate.

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