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M2 cardiac macrophages in wound healing following myocardial infarction: translation to clinic A. Gombozhapova, Y. V. Rogovskaya, M. Rebenkova [et al.]

Contributor(s): Rogovskaya, Yuliya V | Rebenkova, Mariya | Kzhyshkowska, Julia G | Ryabov, Vyacheslav V | Gombozhapova, AleksandraMaterial type: ArticleArticleSubject(s): макрофаги | инфаркта миокарда | постинфарктное ремоделирование левого желудочкаGenre/Form: статьи в журналах Online resources: Click here to access online In: Cardiovascular research Vol. 114, Issue suppl. 1. P. S100Abstract: Funding Acknowledgements: This work was supported by the Russian Foundation for Basic Research (grant №16-04-01268) Introduction: Macrophages play a significant role in transition from inflammatory to regenerative phase during wound healing following myocardial infarction (MI). Despite the progress of experimental investigations on the innate immune response following MI, there is no significant advancement in clinical studies. Purpose: The purpose of the research was to translate experimental knowledge regarding M2 macrophage subsets and their biomarkers in post-infarction left ventricular remodeling and myocardial regeneration into results observed in clinical settings. We suggested protocol based on usage of macrophage biomarkers (scavenger receptors) to study cellular basis of cardiac remodeling in patients...
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Funding Acknowledgements: This work was supported by the Russian Foundation for Basic Research (grant №16-04-01268)
Introduction: Macrophages play a significant role in transition from inflammatory to regenerative phase during wound healing following myocardial infarction (MI). Despite the progress of experimental investigations on the innate immune response following MI, there is no significant advancement in clinical studies.
Purpose: The purpose of the research was to translate experimental knowledge regarding M2 macrophage subsets and their biomarkers in post-infarction left ventricular remodeling and myocardial regeneration into results observed in clinical settings. We suggested protocol based on usage of macrophage biomarkers (scavenger receptors) to study cellular basis of cardiac remodeling in patients...

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