The mechanisms of the antimicrobial function of the mucus layer. Current research gaps N. A. Krivova, O. B. Zaeva
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ArticleContent type: Текст Media type: электронный Subject(s): физиологические механизмы | циркулирующие ферменты | свободные радикалы | слизистые слои | антимикробная функцияGenre/Form: статьи в журналах Online resources: Click here to access online
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Annali d'Italia № 18/1. P. 3-10Abstract: The mucus layer is secreted by epithelial cells. Its antimicrobial function is to prevent the pathogens from entering the epithelial cells. Modern concepts of evolution, composition, structure and protective functions of the mucus layer related to the physical and chemical characteristics of glycoproteins, and the peculiarities of their synthesis and degradation are discussed. Hypotheses about the poorly studied participants in the antimicrobial functions of the mucus layer: the possible virucidal and bactericidal role of circulating enzymes of the digestive tract and anions in the composition of polymerized and degraded glycoproteins are presented. Further research on the physiological mechanisms of the barrier function of the mucus layer may provide a rationale for new means of limiting epidemics of viral and bacterial nature.
Библиогр.: 97 назв.
The mucus layer is secreted by epithelial cells. Its antimicrobial function is to prevent the pathogens from entering the epithelial cells. Modern concepts of evolution, composition, structure and protective functions of the mucus layer related to the physical and chemical characteristics of glycoproteins, and the peculiarities of their synthesis and degradation are discussed. Hypotheses about the poorly studied participants in the antimicrobial functions of the mucus layer: the possible virucidal and bactericidal role of circulating enzymes of the digestive tract and anions in the composition of polymerized and degraded glycoproteins are presented. Further research on the physiological mechanisms of the barrier function of the mucus layer may provide a rationale for new means of limiting epidemics of viral and bacterial nature.
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