Immunomodulatory properties of composite materials based on polylactide and hydroxyapatite I. A. Kurzina, Y. Churina, Y. G. Shapovalova [et al.]
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ArticleSubject(s): биоактивные композиты | иммуномодулирующие свойства | композиционные материалы на основе полилактида | композиционные материалы на основе гидроксиапатитаGenre/Form: статьи в журналах Online resources: Click here to access online
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Bioceramics development and applications Vol. 8, № 1. P. 109 (1-7)Abstract: In the present study composites based on polylactide and hydroxyapatite with the content of components 50:50 and 75:25 were investigated. Components were mixed at 40°C, which was followed by the sonication procedures and its precipitation in ethanol. The analysis of the following composite materials revealed that their chemicalcrystallographic characteristics of individual components remained intact after varying its dispersion and material crystallinity degree. Composite material of the ratio 75:25 were characterized by the lowest degree of crystallinity - 20.5% and the average crystallite size up to 28.8 nm showed an increased roughness and dispersive component of surface energy. In comparison to polylactide, the composite has a high capacity for osseointegration. In the paper, special attention is given to the immunomodulatory properties of composite materials. Assessment of the immune system cells showed that the macrophages are most viable in the presence of pure polylactide and composite 75/25. Intensive secretion of proinflammatory cytokines in macrophage cultures in vitro was not found at that.
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In the present study composites based on polylactide and hydroxyapatite with the content of components 50:50 and 75:25 were investigated. Components were mixed at 40°C, which was followed by the sonication procedures and its precipitation in ethanol. The analysis of the following composite materials revealed that their chemicalcrystallographic characteristics of individual components remained intact after varying its dispersion and material crystallinity degree. Composite material of the ratio 75:25 were characterized by the lowest degree of crystallinity - 20.5% and the average crystallite size up to 28.8 nm showed an increased roughness and dispersive component of surface energy. In comparison to polylactide, the composite has a high capacity for osseointegration. In the paper, special attention is given to the immunomodulatory properties of composite materials. Assessment of the immune system cells showed that the macrophages are most viable in the presence of pure polylactide and composite 75/25. Intensive secretion of proinflammatory cytokines in macrophage cultures in vitro was not found at that.
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