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Oncology disease in patients with acute myocardial infarction with nonobstructive coronary atherosclerosis S. B. Gomboeva, V. V. Ryabov, S. V. Demyanov

By: Gomboeva, S. BContributor(s): Ryabov, Vyacheslav V | Demyanov, S. VMaterial type: ArticleArticleSubject(s): инфаркт миокарда | онкологические заболеванияGenre/Form: статьи в сборниках Online resources: Click here to access online In: The 22nd International Charles Heidelberger symposium on cancer research : proceedings of the International symposium, 17-19 September 2018 P. 33-34Abstract: The aim of this study was to evaluate the cancer incidence among patients with myocardial infarction with nonobstructive coronary atherosclerosis (MINOCA). Material and Methods. The non-randomized controlled study included patients with acute coronary syndrome (ACS) treated between 2010 and 2015. Inclusion criteria comprised NOCA (normal coronary arteries / plaques <50%) confirmed by invasive coronary angiography (CAG) and age over 18 years at the time of randomization. The exclusion criterion was revascularization of the coronary arteries. We compared the study population with patients from POLINCOR study (NCT03122340), which included patients with ACS with obstructive CAD confirmed by invasive CAG, who were admitted to the department of emergency cardiology in 2015-2016 [5]. Results. Among 5794 patients, who were hospitalized with ACS to the Department of Emergency Cardiology in 2010‑2016, 2.8% (161) patients demonstrated nonobstructive coronary atherosclerosis confirmed with CAG. One (0.6%) patient died. There were 94 (58%) cases with acute myocardial infarction, 27 (17%) with unstable angina, 15(9%) with pseudo-coronary scenario of myocarditis, 7 (4%) with cardiomyopathy, and 16 (10%) with arrhythmias, congenital heart defects, aortic dissection. Among the patients with MINOCA, there were 30 (19%) patients with malignant and non-malignant tumors with cancer, including 7 (23%) patients with cancer of kidneys, sigmoid colon and cervix. Bladder cancer was diagnosed in 1 (0.6%) case before admission to the hospital, and lung cancer was identified in 1 (0.6%) case at autopsy. The cancer incidence rate in patients with MINOCA was higher than in patients with obstructive CAD. Conclusion. The proportion of patients with MINOCA among patients with ACS in 2015‑2016 was 2.8 % (161). MINOCA enconpasses a heterogeneous group of diseases, including AMI, unstable angina, myocarditis, cardiomyopathy, arrithmia, aortic dissection and others. Hospital mortality was 0.6%. The cancer incidence in patients with MINOCA was higher than in patients with obstructive CAD.
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The aim of this study was to evaluate the cancer incidence among patients with myocardial
infarction with nonobstructive coronary atherosclerosis (MINOCA). Material and Methods. The
non-randomized controlled study included patients with acute coronary syndrome (ACS) treated
between 2010 and 2015. Inclusion criteria comprised NOCA (normal coronary arteries / plaques
<50%) confirmed by invasive coronary angiography (CAG) and age over 18 years at the time of
randomization. The exclusion criterion was revascularization of the coronary arteries. We compared
the study population with patients from POLINCOR study (NCT03122340), which included
patients with ACS with obstructive CAD confirmed by invasive CAG, who were admitted to the
department of emergency cardiology in 2015-2016 [5]. Results. Among 5794 patients, who were
hospitalized with ACS to the Department of Emergency Cardiology in 2010‑2016, 2.8% (161)
patients demonstrated nonobstructive coronary atherosclerosis confirmed with CAG. One (0.6%)
patient died. There were 94 (58%) cases with acute myocardial infarction, 27 (17%) with unstable
angina, 15(9%) with pseudo-coronary scenario of myocarditis, 7 (4%) with cardiomyopathy, and
16 (10%) with arrhythmias, congenital heart defects, aortic dissection. Among the patients with
MINOCA, there were 30 (19%) patients with malignant and non-malignant tumors with cancer,
including 7 (23%) patients with cancer of kidneys, sigmoid colon and cervix. Bladder cancer was
diagnosed in 1 (0.6%) case before admission to the hospital, and lung cancer was identified in 1
(0.6%) case at autopsy. The cancer incidence rate in patients with MINOCA was higher than in
patients with obstructive CAD. Conclusion. The proportion of patients with MINOCA among
patients with ACS in 2015‑2016 was 2.8 % (161). MINOCA enconpasses a heterogeneous group of
diseases, including AMI, unstable angina, myocarditis, cardiomyopathy, arrithmia, aortic dissection
and others. Hospital mortality was 0.6%. The cancer incidence in patients with MINOCA was
higher than in patients with obstructive CAD.

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