Microarray study of single nucleotide polymorphisms and expression of ATP-binding cassette genes in breast tumors M. M. Tsyganov, M. K. Ibragimova, I. V. Karabut [et.al.]
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ArticleSubject(s): опухоли молочной железы | АТФ-связывающая кассета | однонуклеотидный полиморфизмGenre/Form: статьи в журналах Online resources: Click here to access online
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AIP Conference Proceedings Vol. 1688. P. 03036-1-03036-5Abstract: Our previous research establishes that changes of expression of the ATP-binding cassette genes family is connected with the neoadjuvant chemotherapy effect. However, the mechanism of regulation of resistance gene expression remains unclear. As many researchers believe, single nucleotide polymorphisms can be involved in this process. Thereupon, microarray analysis is used to study polymorphisms in ATP-binding cassette genes. It is thus found that MDR gene expression is connected with 5 polymorphisms, i.e. rs241432, rs241429, rs241430, rs3784867, rs59409230, which participate in the regulation of expression of own genes.
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Our previous research establishes that changes of expression of the ATP-binding cassette genes family is connected with the neoadjuvant chemotherapy effect. However, the mechanism of regulation of resistance gene expression remains unclear. As many researchers believe, single nucleotide polymorphisms can be involved in this process. Thereupon, microarray analysis is used to study polymorphisms in ATP-binding cassette genes. It is thus found that MDR gene expression is connected with 5 polymorphisms, i.e. rs241432, rs241429, rs241430, rs3784867, rs59409230, which participate in the regulation of expression of own genes.
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