TY  - SER
AU  - Gan-Or,Ziv
AU  - Girard,Simon L.
AU  - Montplaisir,Jacques Y.
AU  - Ambalavanan,Amirthagowri
AU  - Strong,Stephanie
AU  - Mallett,Victoria
AU  - Laurent,Sandra B.
AU  - Bourassa,Cynthia V.
AU  - Boivin,Michel
AU  - Mohsin,Noreen
AU  - Langlois,Melanie
AU  - Arnulf,Isabelle
AU  - Högl,Birgit
AU  - Frauscher,Birgit
AU  - Monaca,Christelle
TI  - The role of the melanoma gene MC1R in Parkinson disease and REM sleep behavior disorder
KW  - Паркинсона болезнь
KW  - MC1R
KW  - меланома
KW  - статьи в журналах
N1  - Библиогр.: с. 180.e12-180.e13
N2  - The MC1R gene, suggested to be involved in Parkinson disease (PD) and melanoma, was sequenced in PD patients (n = 539) and controls (n = 265) from New York, and PD patients (n = 551), rapid eye movement sleep behavior disorder (RBD) patients (n = 351), and controls (n = 956) of European ancestry. Sixty-eight MC1R variants were identified, including 7 common variants with frequency > 0.01. None of the common variants was associated with PD or RBD in the different regression models. In a meta-analysis with fixed-effect model, the p.R160W variant was associated with an increased risk for PD (odds ratio = 1.22, 95% confidence interval = 1.02–1.47, p = 0.03) but with significant heterogeneity (p = 0.048). Removing one study that introduced the heterogeneity resulted in nonsignificant association (odds ratio = 1.11, 95% confidence interval, 0.92–1.35, p = 0.27, heterogeneity p = 0.57). Rare variants had similar frequencies in patients and controls (10.54% and 10.15%, respectively, p = 0.75), and no cumulative effect of carrying more than one MC1R variant was found. The present study does not support a role for the MC1R p.R160W and other variants in susceptibility for PD or RBD
UR  - http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000578738
ER  -