TY  - SER
AU  - Riabov,Vladimir B.
AU  - Song,Bin
AU  - Avdic,Aida
AU  - Schledzewski,Kai
AU  - Ovsiy,Ilja
AU  - Gratchev,Alexei N
AU  - Verdiell,Maria Llopis
AU  - Sticht,Carsten
AU  - Schmuttermaier,Christina
AU  - Yin,Shuiping
AU  - Schönhaber,Hiltrud
AU  - Weiss,Christel
AU  - Fields,Alan P.
AU  - Simon-Keller,Katja
AU  - Pfister,Frederick
AU  - Berlit,Sebastian
AU  - Marx,Alexander
AU  - Arnold,Bernd
AU  - Goerdt,Sergij
AU  - Kzhyshkowska,Julia G.
TI  - Stabilin-1 is expressed in human breast cancer and supports tumor growth in mammary adenocarcinoma mouse model
KW  - рак молочной железы
KW  - Stabilin-1
KW  - макрофаги
KW  - статьи в журналах
N1  - Библиогр.: 57 назв
N2  - Stabilin-1 is a multifunctional scavenger receptor expressed on alternatively-activated macrophages. Stabilin-1 mediates phagocytosis of "unwanted-self" components, intracellular sorting, and endocytic clearance of extracellular ligands including SPARC that modulates breast cancer growth. The expression of stabilin-1 was found on tumor-associated macrophages (TAM) in mouse and human cancers including melanoma, lymphoma, glioblastoma, and pancreatic insulinoma. Despite its tumor-promoting role in mouse models of melanoma and lymphoma the expression and functional role of stabilin-1 in breast cancer was unknown. Here, we demonstrate that stabilin-1 is expressed on TAM in human breast cancer, and its expression is most pronounced on stage I disease. Using stabilin-1 knockout (ko) mice we show that stabilin-1 facilitates growth of mouse TS/A mammary adenocarcinoma. Endocytosis assay on stabilin-1 ko TAM demonstrated impaired clearance of stabilin-1 ligands including SPARC that was capable of inducing cell death in TS/A cells. Affymetrix microarray analysis on purified TAM and reporter assays in stabilin-1 expressing cell lines demonstrated no influence of stabilin-1 expression on intracellular signalling. Our results suggest stabilin-1 mediated silent clearance of extracellular tumor growth-inhibiting factors (e.g. SPARC) as a mechanism of stabilin-1 induced tumor growth. Silent clearance function of stabilin-1 makes it an attractive candidate for delivery of immunomodulatory anti-cancer therapeutic drugs to TAM
UR  - http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000576656
ER  -