TY  - GEN
AU  - Rafailov,E.U.
AU  - Sokolovsky,S.G.
AU  - Borisova,Ekaterina G.
AU  - Mantareva,Vanya
AU  - Angelov,Ivan
AU  - Shirokov,Alexander
AU  - Navolokin,Nikita A.
AU  - Shushunova,Natalia A.
AU  - Khorovodov,Alexander P.
AU  - Semyachkina-Glushkovskaya,Oxana V.
AU  - Terskov,Andrey V.
AU  - Bodrova,Anastasia A.
AU  - Ulanova,Mariya V
AU  - Shrif,Esmat
AU  - Tuchin,Valery V.
AU  - Kurths,Jürgen
TI  - The laser technologies of targeted opening of blood-brain barrier for drug brain delivery
KW  - гематоэнцефалический барьер
KW  - лазерные технологии
KW  - фотодинамическая терапия
KW  - статьи в сборниках
N2  - Here we show the photodynamic treatment
(PDT) causes significant increase in the permeability of the
 blood-brain barrier (BBB) in healthy mice. Using different
 doses of laser (635 nm, 10-40 J/cm2) and photosensitizer (5-
 aminole-vulinic acid – 5-ALA, 20 and 80 mg/kg, i.v.), we
 found the optimal PDT for the reversible opening of BBB
 that is 15 J/cm2 and 5-ALA, 20 mg/kg, when the brain
 tissues recover 3 days later. Further increase in the laser
 or 5-ALA doses has not amplifying effect on the BBB but
 associated with severe damages of brain tissues. These
 results can be good informative platform for the further
 studies of new strategies in brain drug delivery and for the
 better understanding of mechanisms underlying
 cerebrovascular effects of PD-related fluorescence guided
 resection of brain tumor
UR  - http://vital.lib.tsu.ru/vital/access/manager/Repository/vtls:000659761
ER  -