TY  - SER
AU  - Udut,Vladimir V.
AU  - Naumov,Sergei Alexandrovich
AU  - Udut,Elena V.
AU  - Naumov,Sergei Sergeevich
AU  - Evtushenko,Diana Nikolaevna
AU  - Chumakova,O.N.
AU  - Zyuzkov,Gleb N.
TI  - Mechanisms of the effects of short-term inhalations of Xe and O2 gas mixture in the rehabilitation of post-covid ventilation failure
KW  - постковидные осложнения
KW  - легочный сурфактант
KW  - дипальмитоилфосфатидилхолин
KW  - молекулярный электростатический потенциал
KW  - ингаляции газовой смесью ксенона и кислорода
KW  - статьи в журналах
N1  - Библиогр.: 15 назв
N2  - The article presents a theoretical rationale and a clinical case of relief of post-COVID ventilation failure by inhalation of Xe and O-2 gas mixture. Pneumonitis of coronavirus etiology transforms saturated phospholipids of surfactant into a solid-ordered phase, which disrupts surface tension, alveolar pneumatization, and alveolar-capillary gas exchange. Using molecular modeling (B3LYP/lanl2dz; GAUSSIAN09), we demonstrated that Xe atom due to the van der Waals dispersion interaction increases the distance between the phospholipid acyl chains providing a phase transition from the solid-ordered to liquid phase and restored the surface-active monolayer surfactant film. A clinical case confirmed that short-term inhalations of the Xe and O-2 gas mixture relieved manifestations of ventilation insufficiency and increased SpO(2) and pneumatization of the terminal parts of the lungs
UR  - http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001004091
ER  -