TY  - SER
AU  - Stakheyeva,Marina N.
AU  - Patysheva,Marina R.
AU  - Kaigorodova,Evgeniya V.
AU  - Zavyalova,Marina V.
AU  - Tarabanovskaya,Natalia A.
AU  - Choynzonov,Evgeny L.
AU  - Cherdyntseva,Nadezhda V.
TI  - Tumor properties mediate the relationship between peripheral blood monocytes and tumor-associated macrophages in breast cancer
KW  - рак молочной железы
KW  - моноциты
KW  - опухолеассоциированные макрофаги
KW  - циркулирующие опухолевые клетки
KW  - статьи в журналах
N1  - Библиогр.: 65 назв
N2  - In cancer patients, circulating monocytes show functional alterations. Since monocytes are precursors of tumor-associated macrophages (TAMs), TAMs ensuring tumor viability are potentially replenished through the recruitment of monocytes with specific properties. We demonstrated that locoregional metastasis and circulating factors, such as CD45-EpCAM + CD44 + CD24-/low circulating tumor cells, and serum MCP-1 and HMGB1 were statistically associated with modulation of the monocyte features in breast cancer patients. The count of circulating CD45-EpCAM + cells correlated with CD68+, CD163 + monocyte in blood, and with density of CD68 + TAM in breast cancer tumors. Overall, the relationship between monocytes and TAMs is mediated by the tumor in breast cancer patients
UR  - http://vital.lib.tsu.ru/vital/access/manager/Repository/koha:001003659
ER  -