Разработка методики изучения антимикробной активности прототипов твердых лекарственных форм с функцией контролируемого высвобождения антибиотиков А. В. Болтовская, Д. А. Федоришин, А. А. Волохова
Material type:
ArticleContent type: Текст Media type: электронный Other title: Development of a method for studying antimicrobial activity of solid drug dosage forms prototypes with the function of controlled release of antibiotics [Parallel title]Subject(s): антимикробная активность | твердые лекарственные формы | высвобождение лекарственных средств | экспериментальные исследованияGenre/Form: статьи в сборниках Online resources: Click here to access online
In:
Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XVIII Международной конференции студентов, аспирантов и молодых ученых, 27–30 апреля 2021 г Т. 4 : Биология и фундаментальная медицина. С. 10-12Abstract: Currently, there are many methods for testing the antibacterial activity of solid dosage forms intended for targeted delivery and controlled release of drugs. The standard diffusion method has a number of limitations, the main one of which is the impossibility of assessing the antibacterial activity of samples in vitro under conditions of skin damage. Infiltration method has been developed, which allows a deeper assessment of the antibacterial activity of solid dosage forms. As a result of a study on a polymer scaffold model, it was found that targeted delivery of chloramphenicol can potentially increase the growth inhibition of both S. aureus and E. coli, which will further reduce the systemic dose of drugs prescribed to patients.
Библиогр.: 3 назв.
Currently, there are many methods for testing the antibacterial activity of solid dosage forms intended for targeted delivery and controlled release of drugs. The standard diffusion method has a number of limitations, the main one of which is the impossibility of assessing the antibacterial activity of samples in vitro under conditions of skin damage. Infiltration method has been developed, which allows a deeper assessment of the antibacterial activity of solid dosage forms. As a result of a study on a polymer scaffold model, it was found that targeted delivery of chloramphenicol can potentially increase the growth inhibition of both S. aureus and E. coli, which will further reduce the systemic dose of drugs prescribed to patients.
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