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Дисбаланс эндоцитоза в опухолеассоциированных макрофагах рака молочной железы под влиянием химиотерапии in vitro П. С. Ямщиков, И. В. Ларионова, Е. О. Казакова

By: Ямщиков, Павел СергеевичContributor(s): Ларионова, Ирина Валерьевна | Казакова, Елена ОлеговнаMaterial type: ArticleArticleContent type: Текст Media type: электронный Other title: Endocytosis imbalance in the breast cancer tumor associated macrophages under chemotherapy impact in vitro [Parallel title]Subject(s): биоинформатический анализ | опухолеассоциированные макрофаги | рак молочной железы | цисплатинGenre/Form: статьи в сборниках Online resources: Click here to access online In: Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XVIII Международной конференции студентов, аспирантов и молодых ученых, 27–30 апреля 2021 г Т. 4 : Биология и фундаментальная медицина. С. 106-108Abstract: Chemotherapy resistance remains one of the main challenges in cancer therapy. There are numerous complications involved in chemotherapy resistance, and implication of tumor associated macrophages (TAMs) is one of them. In the present study for the first time, we have analyzed the influence of chemotherapeutic drug cisplatin on the ability of macrophages to scavenge the regulatory components of the tumor microenvironment (TME). We used an ex vivo system of TAMs, reprogrammed by conditioned tumor supernatants of breast cancer (MCF-7) cell lines. The cisplatin treated/untreated TAMs were examined through the full-transcriptome nextgeneration sequencing (NGS). The endocytosis pathways were evaluated via several bioinformatical approaches.
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Chemotherapy resistance remains one of the main challenges in cancer therapy. There are numerous complications involved in chemotherapy resistance, and implication of tumor associated macrophages (TAMs) is one of them. In the present study for the first time, we have analyzed the influence of chemotherapeutic drug cisplatin on the ability of macrophages to scavenge the regulatory components of the tumor microenvironment (TME). We used an ex vivo system of TAMs, reprogrammed by conditioned tumor supernatants of breast cancer (MCF-7) cell lines. The cisplatin treated/untreated TAMs were examined through the full-transcriptome nextgeneration sequencing (NGS). The endocytosis pathways were evaluated via several bioinformatical approaches.

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