Влияние химиотерапевтических препаратов на жизнеспособность опухолевых клеток рака толстой кишки в ко-культуре с макрофагами М. А. Ракина, А. Д. Казакова, А. А. Евтина
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ArticleContent type: Текст Media type: электронный Other title: The effect of chemotheraputic agents on viability of colorectal cancer cells in co-culture with macrophages [Parallel title]Subject(s): колоректальный рак | химиотерапевтические препараты | опухолевые клетки | экспериментальные исследованияGenre/Form: статьи в сборниках Online resources: Click here to access online
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Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XVIII Международной конференции студентов, аспирантов и молодых ученых, 27–30 апреля 2021 г Т. 4 : Биология и фундаментальная медицина. С. 67-69Abstract: Colorectal cancer (CRC) is considered as one of the most common and fatal malignancies in the world. [1]. Tumor-associated macrophages (TAM) are key cells of innate immunity that constitute up to 50% of cells from tumor microenvironment and play a crucial role in tumor progression [2]. Chemotherapy (CT) is considered as one of the main types of anticancer treatment for solid tumors. However, in colon cancer its effectiveness is lacking due to a variety of reasons. One of them is TAMs and, in particular, their involvement in the effect of CT and the lack of tumor response to it [2]. Thus, we studied the effect of CT agents on viability of CRC cells in vitro and also established a co-culture of monocyte derived macrophages and tumor cells.
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Colorectal cancer (CRC) is considered as one of the most common and fatal malignancies in the world. [1]. Tumor-associated macrophages (TAM) are key cells of innate immunity that constitute up to 50% of cells from tumor microenvironment and play a crucial role in tumor progression [2]. Chemotherapy (CT) is considered as one of the main types of anticancer treatment for solid tumors. However, in colon cancer its effectiveness is lacking due to a variety of reasons. One of them is TAMs and, in particular, their involvement in the effect of CT and the lack of tumor response to it [2]. Thus, we studied the effect of CT agents on viability of CRC cells in vitro and also established a co-culture of monocyte derived macrophages and tumor cells.
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