Прогностическая значимость белков CD8 И IL35 в строме рака толстой кишки Е. О. Казакова, И. В. Ларионова, М. А. Ракина
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ArticleContent type: Текст Media type: электронный Other title: Prognostic value of CD8 and IL35 in colon cancer [Parallel title]Subject(s): колоректальный рак | опухолеассоциированные макрофаги | экспериментальные исследования | иммуногистохимические исследованияGenre/Form: статьи в сборниках Online resources: Click here to access online
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Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XVII Международной конференции студентов, аспирантов и молодых ученых, Россия, Томск, 21-24 апреля 2020 г Т. 4 : Биология и фундаментальная медицина. С. 34-36Abstract: To date, colorectal cancer (CRC) remains a major health problem around the globe [1]. Tumor- associated macrophages (TAM) are currently considered as a very promising target for chemotherapy [2]. However in colon cancer the role of TAMs remains controversial. Thus, we studied the immune status of colorectal tumors and found that a decrease in the level of CD8 and IL35 indicates a poor prognosis and increased likelihood of lymphatic, but not hematogenous metastasis. Moreover, we have shown that IL35 is expressed in tumor-associated macrophages in colorectal cancer.
Библиогр.: 3 назв.
To date, colorectal cancer (CRC) remains a major health problem around the globe [1]. Tumor- associated macrophages (TAM) are currently considered as a very promising target for chemotherapy [2]. However in colon cancer the role of TAMs remains controversial. Thus, we studied the immune status of colorectal tumors and found that a decrease in the level of CD8 and IL35 indicates a poor prognosis and increased likelihood of lymphatic, but not hematogenous metastasis. Moreover, we have shown that IL35 is expressed in tumor-associated macrophages in colorectal cancer.
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