Prognostic significance of TGF-B-associated proteins in breast cancer patients treated with adjuvant tamoxifen T. A. Dronova, N. N. Babyshkina, S. V. Patalyak, N. V. Cherdyntseva
Material type:
ArticleSubject(s): рак молочной железы | адъювантная терапия | тамоксифен | трансформирующий ростовой фактор бета, белокGenre/Form: статьи в сборниках Online resources: Click here to access online
In:
The 22nd International Charles Heidelberger symposium on cancer research : proceedings of the International symposium, 17-19 September 2018 P. 25-26Abstract: We investigated the effect of 3 TGF-β-associated signaling components (TGF-β1, TGF-βR1,
TGF-βR2) and ERα on the response to adjuvant tamoxifen treatment in 122 estrogen positive
breast cancer patients. Our data suggest that the gene and protein expression of TGF-βR1 as well
as ESR1 rs2228480 and the distribution pattern of ERα expression may play a significant role in
the development of tamoxifen resistance/sensitive in breast cancer patients.
Библиогр.: 2 назв.
We investigated the effect of 3 TGF-β-associated signaling components (TGF-β1, TGF-βR1,
TGF-βR2) and ERα on the response to adjuvant tamoxifen treatment in 122 estrogen positive
breast cancer patients. Our data suggest that the gene and protein expression of TGF-βR1 as well
as ESR1 rs2228480 and the distribution pattern of ERα expression may play a significant role in
the development of tamoxifen resistance/sensitive in breast cancer patients.
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