Индекс метилирования импринтированных генов GNAS и GRB10 при нарушениях эмбрионального развития человека А. А. Кадралиева
Material type:
ArticleOther title: Methylation index of imprinted GNAS and GRB10 genes in abnormal human embryo development [Parallel title]Subject(s): геномный импринтинг | эмбриональное развитие | метилирование | экспрессия геновGenre/Form: статьи в сборниках Online resources: Click here to access online
In:
Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XV Международной конференции студентов, аспирантов и молодых ученых, 24-27 апреля 2018 г Т. 4 : Биология и фундаментальная медицина. С. 60-62Abstract: The present study analyzes the methylation index of the imprinted GNAS and GRBIO genes in the group of the first trimester spontaneous abortions with normal karyotype. The DNA samples derived from extraembryonic mesoderm of 47 spontaneous abortions and 45 induced abortions were examined. A significant increase in the methylation index of the imprinted GNAS gene and a decrease in the GRBIO in the spontaneous abortions were observed. Based on the function of this imprinted genes, it can be assumed that an increase in the methylation index of the GNAS gene and its decrease in the GRBIO could enhance the suppression of embryo growth and lead to a possible disturbance of embryo development.
Библиогр.: 4 назв.
The present study analyzes the methylation index of the imprinted GNAS and GRBIO genes in the group of the first trimester spontaneous abortions with normal karyotype. The DNA samples derived from extraembryonic mesoderm of 47 spontaneous abortions and 45 induced abortions were examined. A significant increase in the methylation index of the imprinted GNAS gene and a decrease in the GRBIO in the spontaneous abortions were observed. Based on the function of this imprinted genes, it can be assumed that an increase in the methylation index of the GNAS gene and its decrease in the GRBIO could enhance the suppression of embryo growth and lead to a possible disturbance of embryo development.
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