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Heterogeneity in breast tumor microenvironment: A report from one case L. A. Tashireva, E. V. Denisov, O. E. Savelieva [et.al.]

Contributor(s): Tashireva, Liubov A | Savelieva, Olga E | Zavyalova, Marina V | Kaigorodova, Evgeniya V | Slonimskaya, Elena M | Perelmuter, Vladimir M | Denisov, Evgeny VMaterial type: ArticleArticleSubject(s): рак молочной железы | внутренняя морфологическая гетерогенностьGenre/Form: статьи в журналах Online resources: Click here to access online In: European journal of cancer supplements Vol. 13, № 1. P. 61Abstract: Intratumoral heterogeneity contributes significantly to the effectiveness of cancer treatment and outcome (Ng C.K., Pemberton H.N., Reis-Filho J.S., 2012). Previously the phenomenon of intratumoral morphological heterogeneity was demonstrated in breast cancer and it was found that the presence of alveolar structures in breast tumors is associated with high frequency of lymphogenic metastasis (Zavyalova M.V. et al., 2013a; Zavyalova M.V. et al. 2013b; Denisov E.V. et al., 2014). Tumor microenvironment (ME) is a key factor in determining the properties of the invasive and metastatic potential of the tumor and seems to be also heterogeneous. Analysis of the ME in patients with different solid tumors reveals that the majority of tumors show a T cell–infiltrated phenotype. Macrophages, fibroblasts, dendric cells etc. are also located in the ME and show their effects. The aim of this work was to determine the expression of key markers of cells which are presented in the ME of the various morphological structures.
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Intratumoral heterogeneity contributes significantly to the effectiveness of cancer treatment and outcome (Ng C.K., Pemberton H.N., Reis-Filho J.S., 2012). Previously the phenomenon of intratumoral morphological heterogeneity was demonstrated in breast cancer and it was found that the presence of alveolar structures in breast tumors is associated with high frequency of lymphogenic metastasis (Zavyalova M.V. et al., 2013a; Zavyalova M.V. et al. 2013b; Denisov E.V. et al., 2014). Tumor microenvironment (ME) is a key factor in determining the properties of the invasive and metastatic potential of the tumor and seems to be also heterogeneous. Analysis of the ME in patients with different solid tumors reveals that the majority of tumors show a T cell–infiltrated phenotype. Macrophages, fibroblasts, dendric cells etc. are also located in the ME and show their effects. The aim of this work was to determine the expression of key markers of cells which are presented in the ME of the various morphological structures.

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