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Assessing the effects of riboflavin/UV-A crosslinking on porcine corneal mechanical anisotropy with optical coherence elastography M. Singh, J. Li, Z. Han [et.al.]

Contributor(s): Singh, Manmohan | Han, Zhaolong | Raghunathan, Raksha | Nair, Achuth | Wu, Chen | Liu, Chih-Hao | Aglyamov, Salavat R | Twa, Michael D | Larin, Kirill V | Li, JiasongMaterial type: ArticleArticleSubject(s): эластография | роговица глаза | сшивание роговичного коллагена | рибофлавин | механическая анизотропия | Юнга модульGenre/Form: статьи в журналах Online resources: Click here to access online In: Biomedical optics express Vol. 8, № 1. P. 349-366Abstract: In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of in situ porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Young’s modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the Young’s modulus and elastic anisotropy of the cornea and their changes as a function of IOP and CXL, opening new avenues of research for evaluating the effects of CXL on corneal biomechanical properties.
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In this work we utilize optical coherence elastography (OCE) to assess the effects of UV-A/riboflavin corneal collagen crosslinking (CXL) on the mechanical anisotropy of in situ porcine corneas at various intraocular pressures (IOP). There was a distinct meridian of increased Young’s modulus in all samples, and the mechanical anisotropy increased as a function of IOP and also after CXL. The presented noncontact OCE technique was able to quantify the Young’s modulus and elastic anisotropy of the cornea and their changes as a function of IOP and CXL, opening new avenues of research for evaluating the effects of CXL on corneal biomechanical properties.

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