Laser speckle contrast imaging of cerebral blood flow of newborn mice at optical clearing P. A. Timoshina, E. M. Zinchenko, D. K. Tuchina [et.al.]
Material type:
ArticleSubject(s): лазерная спекл-контрастная визуализация | церебральный кровоток | новорожденные мышиGenre/Form: статьи в журналах Online resources: Click here to access online
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Proceedings of SPIE Vol. 10336 : Saratov Fall Meeting 2016 : Optical Technologies in Biophysics and Medicine XVIII, 27-30 September 2016, Saratov, Russian Federation. P. 1033610-1-1033610-7Abstract: In this work, we consider the use of optical clearing agents to improve imaging quality of the cerebral blood flow of newborn mice. Aqueous 60%-glycerol solution, aqueous 70%-OmnipaqueTM(300) solution and OmnipaqueTM (300) solution in water/DMSO(25%/5%) were selected as the optical clearing agents. Laser speckle contrast imaging (LSCI) was used for imaging of cerebral blood flow in newborn mice brain during topical optical clearing of tissuesin the area of the fontanelle. These results demonstrate the effectiveness of glycerol and Omnipaque solutions as optical clearing agents for investigation of cerebral blood flow in newborn mice without scalp removing and skull thinning.
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In this work, we consider the use of optical clearing agents to improve imaging quality of the cerebral blood flow of newborn mice. Aqueous 60%-glycerol solution, aqueous 70%-OmnipaqueTM(300) solution and OmnipaqueTM (300) solution in water/DMSO(25%/5%) were selected as the optical clearing agents. Laser speckle contrast imaging (LSCI) was used for imaging of cerebral blood flow in newborn mice brain during topical optical clearing of tissuesin the area of the fontanelle. These results demonstrate the effectiveness of glycerol and Omnipaque solutions as optical clearing agents for investigation of cerebral blood flow in newborn mice without scalp removing and skull thinning.
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