Role of cAMP- and IKK-2-dependent signaling pathways in functional stimulation of mesenchymal progenitor cells with alkaloid songorine G. N. Zyu'kov, V. V. Zhdanov, E. V. Udut [et.al.]
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ArticleSubject(s): клетки-предшественники | мезенхимальные клеткиGenre/Form: статьи в журналах Online resources: Click here to access online
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Bulletin of experimental biology and medicine Vol. 159, № 5. P. 642-645Abstract: The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation.
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The role of cAMP- and IKK-2-dependent pathways in stimulation of the growth capacity of mesenchymal progenitor cells with alkaloid songorine was studied in vitro. Inhibitors of adenylate cyclase and IKK-2 were shown to abolish the increase in proliferative activity of progenitor cells. Moreover, blockade of the inhibitory kinase complex was accompanied by a decrease in the intensity of progenitor cell differentiation.
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