Endogenous ADP-Ribosylation electronic resource edited by Friedrich Koch-Nolte.
Material type: TextSeries: Current Topics in Microbiology and ImmunologyPublication details: Cham : Springer International Publishing : Imprint: Springer, 2015Description: VIII, 213 p. online resourceContent type: text Media type: computer Carrier type: online resourceISBN: 9783319107714Subject(s): medicine | Immunology | Medical Microbiology | pharmacology | Biomedicine | Pharmacology/Toxicology | Medical Microbiology | ImmunologyDDC classification: 615 LOC classification: RM1-950Online resources: Click here to access onlineThe natural history of ADP-ribosyltransferases and the ADP ribosylation system -- Identification and Analysis of ADP-ribosylated Proteins -- Photorhabdus luminescens toxins TccC3 and TccC5: Insecticidal ADP-ribosyltransferases that modify threonine and glutamine -- Reaction mechanism of mono-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein -- Regulation of nitrogenase by reversible mono-ADP-ribosylation -- ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells -- Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish -- Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family -- Function and regulation of the mono-ADP-ribosyltransferase ARTD10 -- Regulation of nucleocytoplasmic transport by ADP-ribosylation: the emerging role of karyopherin-β1 mono-ADP-ribosylation by ARTD15.
This volume gathers the latest exciting findings on ADP-ribosylation from renowned experts in the field. It includes ten chapters, organized into the following three thematic sections: · Evolution and detection of endogenous ADP-ribosylation · ADP-ribosylation by the ARTC family of ADP-ribosyltransferases (R-S-E ARTs) · ADP-ribosylation by the ARTD family of ADP-ribosyltransferases (H-Y-E ARTs) The book will provide readers a better understanding of ADP-ribosylating toxins and their endogenous relatives. This provides a basis for developing novel toxin-neutralizing drugs and drugs targeting endogenous ADP-ribosyltransferase relatives.
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