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Адаптивная эволюция генетического разнообразия в популяциях человека. Поиск сигналов направленного отбора в популяциях Северной Евразии В. А. Степанов, В. Н. Харьков, Т. В. Татаринова

By: Степанов, Вадим АнатольевичContributor(s): Харьков, Владимир Николаевич, 1979- | Татаринова, Татьяна ВладимировнаMaterial type: ArticleArticleOther title: Adaptive evolution of genetic diversity in human populations. Search of the signals of positive selection in populations of North Eurasia [Parallel title]Subject(s): Север Евразии | популяции человека | адаптивная эволюция | генетическое разнообразие | естественный отборGenre/Form: статьи в сборниках Online resources: Click here to access online In: Эволюция жизни на Земле : материалы V Международного симпозиума, 12-16 ноября 2018 г С. 47-49Abstract: Adaptation to cold climate in human populations of North Eurasia, mediated by natural selection, could lead to specific patterns of genetic diversity in the genomic regions involved in potentially adaptive phenotypic traits. We have performed the genome-wide search of the signals on selection in 5 human populations from North Eurasia based on the analysis of genomic regions of extended homozygosity. Around 100-200 long homozygous blocks has been found in each population. Significant number of these blocks are located within the regions of genes involved in energy metabolism and thermoregulation, reflecting the driven changes of genetic diversity related to the adaptation to climatic and geographic conditions.
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Adaptation to cold climate in human populations of North Eurasia, mediated by natural selection, could lead to specific
patterns of genetic diversity in the genomic regions involved in potentially adaptive phenotypic traits. We have performed the
genome-wide search of the signals on selection in 5 human populations from North Eurasia based on the analysis of genomic
regions of extended homozygosity. Around 100-200 long homozygous blocks has been found in each population. Significant
number of these blocks are located within the regions of genes involved in energy metabolism and thermoregulation, reflecting
the driven changes of genetic diversity related to the adaptation to climatic and geographic conditions.

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