Характеристика транскриптома циркулирующих моноцитов при раке молочной железы Е. А. Простакишина, П. С. Ямщиков, А. А. Фролова
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ArticleContent type: Текст Media type: электронный Other title: Transcriptome сharacterizatюn of the circulating monocytes in breast cancer patients [Parallel title]Subject(s): рак молочной железы | циркулирующие опухолевые клетки | экспериментальные исследованияGenre/Form: статьи в сборниках Online resources: Click here to access online
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Перспективы развития фундаментальных наук. Т. 4 : сборник научных трудов XIX Международной конференции студентов, аспирантов и молодых ученых, 26-29 апреля 2022 г Т. 4 : Биология и фундаментальная медицина. С. 56-58Abstract: Circulating monocytes are the main source of tumor-associated macrophages. It has been shown that blood monocytes can have certain transcriptional, epigenetic, and metabolic programs mediated by the presence of solid carcinomas. On the other hand, monocytes are direct participants in inflammation, which is a significant pathogenetic factor in neoplasia. The aim of the research was to investigate the extent to which the transcriptome profile of monocytes is associated with the presence of breast cancer (BC) and whether the obtained data can be of clinical value. It was found that the transcriptome of monocytes in BC differs from the transcriptome of monocytes of healthy women for the CD14+ cells. 31 genes were also identified with overexpression with adj.p.val<0.05 and log2FC≥0.75 in monocytes in BC. Data were obtained on a significant increase in the level of transcripts of the ABCA1, DDIT4, PLIN1 and CXCR4 genes in BC group during the validation of the results of the monocyte transcriptome.
Библиогр.: 3 назв.
Circulating monocytes are the main source of tumor-associated macrophages. It has been shown that blood monocytes can have certain transcriptional, epigenetic, and metabolic programs mediated by the presence of solid carcinomas. On the other hand, monocytes are direct participants in inflammation, which is a significant pathogenetic factor in neoplasia. The aim of the research was to investigate the extent to which the transcriptome profile of monocytes is associated with the presence of breast cancer (BC) and whether the obtained data can be of clinical value. It was found that the transcriptome of monocytes in BC differs from the transcriptome of monocytes of healthy women for the CD14+ cells. 31 genes were also identified with overexpression with adj.p.val<0.05 and log2FC≥0.75 in monocytes in BC. Data were obtained on a significant increase in the level of transcripts of the ABCA1, DDIT4, PLIN1 and CXCR4 genes in BC group during the validation of the results of the monocyte transcriptome.
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