Magnetic-responsive doxorubicin-containing materials based on Fe3O4 nanoparticles with a SiO2/PEG shell and study of their effects on cancer cell lines A. M. Demin, A. V. Vakhrushev, A. G. Pershina [et al.]
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ArticleContent type: Текст Media type: электронный Subject(s): магнитные наночастицы | доксорубицин | магнитное поле | опухолевые клеткиGenre/Form: статьи в журналах Online resources: Click here to access online
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International journal of molecular sciences Vol. 23, № 16. P. 9093 (1-14)Abstract: Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid-polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.
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Novel nanocomposite materials based on Fe3O4 magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid-polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.
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